Science Advances Paper on SCR Antivirals
New paper out in Science Advances: a library of synthetic carbohydrate receptors (SCRs)—small molecules that bind viral N-glycans—blocks viral entry across coronaviruses, paramyxoviruses, and filoviruses, with single-dose protection in a severe SARS-CoV-2 mouse model.
Our team was a small but significant part of this: David Onofrei collected and we analyzed saturation transfer difference (STD)-NMR data to verify direct engagement of the SCR with the SARS-CoV-2 spike receptor-binding domain (RBD) in solution (see Fig. 4B). That mechanistic confirmation complements the cell and animal data and supports glycan-targeting as a broad-spectrum antiviral strategy.
Proud to contribute alongside an amazing, multidisciplinary team.
https://www.science.org/doi/10.1126/sciadv.ady3554
