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Holland Lab | Publications
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Stengel, D., Addison, J.B., Onofrei, D., Huynh, N.U., Youssef, G., Holland, G.P. “Hydration-Induced β-sheet Crosslinking of α-helical-rich Spider Prey-Wrapping Silk” Adv. Funct. Mater. 2021, 31, 2007161. IF = 16.836

Onofrei, D., Stengel, D., Jia, D., Johnson, H.R., Trescott, S., Soni, A., Addison, B., Muthukumar, M., Holland, G.P. “Investigating the Atomic and Mesoscale Interactions that Facilitate Spider Silk Protein Pre-assembly” Biomacromolecules 2021, 22, 3377-3385. IF = 6.988

Swanson, H.L., Pokhrel, S., Davidowski, S.K., Mädler, L., Brinker, C.J., Holland, G.P. “The Impact of Metal Doping on Fumed Silica Structure and Amino Acid Thermal Condensation Catalytic Properties” J. Mater. Sci. 2021, 56, 16916-16927. IF = 4.22


Swanson, H.L., Guo, C., Cao, M., Addison J.B. and Holland, G.P.“Probing the Binding Modes and Dynamics of Histidine on Fumed Silica Surfaces by Solid-state NMR” Phys. Chem .Chem. Phys. 2020, 22, 20349-20361. IF = 3.567

Addison, J.B., Stengel, D., Bharadwaj, V.S., Happs, R.M., Doeppke, C., , Wang, T., Bomble, Y.J., Holland, G.P., Harman-Ware, A.E. “Selective 1D 13C-13C Spin-Diffusion Solid-State NMR Methods to Probe Spatial Arrangements in Biopolymers” J. Phys. Chem. B. 2020, 124, 9870-9083. IF = 2.857


McGill, M., Holland, G.P., Kaplan, D.L. “Experimental Methods for Characterizing the Secondary Structure and Thermal Properties of Silk Proteins” Macromol. Rapid Commun. 2019, 40, 1800390. IF = 4.265

Kim, Y.H., Leriche, G., Diraviyam, K., Koyanagi, T., Gao, K., Onofrei, D., Patterson, J., Guha, A., Gianneschi, N., Holland, G.P., Gilson, M.K., Mayer, M., Sept, D., Yang, J. “Entropic Effects Enable Life at Extreme Temperatures” Science Advances 2019, 5, eaaw4783. IF = 12.804

Leriche, G., Onofrei, D., Stengel, D. Koyanagi, T., Holland, G.P., Yang, J. “Fusion of Bipolar Tetraether Lipid Membranes Without Enhanced Leakage of Small Molecules” Sci. Rep. 2019, 9, 1-11. IF = 4.122

Irazema, J.I., Stengel, D., Garcia, C.A., Addison, J.B., Samaan, G.N., Holland, G.P., Purse, B.W. “2H NMR Reveals Liquid State-like Dynamics of Arene Guests Inside Hexameric Pyrogallo[4]arene Capsules in the Solid State” Organic Chemistry Frontiers 2019, 6, 1361-1366. IF = 4.693

Polido, G., Xhi, X., Xu, D., Guo, C., Thai, R., Patterson, J.P., Gianneschi, N.C., Suchyna, T.M., Sachs, F., Holland, G.P. “Investigating the Interaction of Grammostola rosea Venom Peptides and Model Lipid Bilayers with Solid-state NMR and Electron Microscopy Techniques” Biochim. Biophys. Acta 2019, 1861, 151-160.* IF = 3.687

Parent, L.R., Onofrei, D., Xu, D., Stengel, D., Roehling, J.D., Addison, J.B., Forman, C. Amin, S.A, Cherry, B.R., Yarger, J.L., Gianneschi, N.C., Holland, G.P. “Hierarchical Spidroin Micellar Nanoparticles as the Precursors of Spider Silks” Microsc. Microanal. 2019, 25, 1346-1347.* IF = 2.673


Addison, B., Onofrei, D., Stengel, D., Blass, B., Brenneman, B., Ayon, J., Holland, G.P. “Spider Prey Wrapping Silk is an α-helical Coiled-coil/β-sheet Hybrid Nanofiber” Chem. Commun. 2018, 54, 10746-10749. IF = 6.290

Parent, L.R., Onofrei, D., Xu, D., Stengel, D., Roehling, J.D., Addison, J.B., Forman, C. Amin, S.A, Cherry, B.R., Yarger, J.L., Gianneschi, N.C., Holland, G.P. “Hierarchical Spidroin Micellar Nanoparticles as the Fundamental Precursors of Spider Silks” Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 11507-11512. IF = 9.661; Highlighted in The Washington Post, Newsweek, and C&E News


Journey, S.N., Teppang, K.L., Garcia, C.A., Brim, S.A., Onofrei, D., Addison, J.B., Holland, G.P., Purse, B.W. “Mechanically Induced Pyrogallol [4] arene Hexamer Assembly in the Solid State Extends the Scope of Molecular Encapsulation” Chemical Science. 2017, 8, 7737–7745. IF = 8.668

Koyanagi, G., Cifelli, J.L., Leriche, G., Yep, Onofrei, D., Holland, G.P., Yang, J. “Thiol-triggered Release of Intraliposomal Content from Liposomes made of Extremophile-inspired Tetraether Lipids” Bioconjugate Chem. 201728, 2041-2045. IF = 4.818

Guo, C., Jordan, J.S., Yarger, J.L., Holland, G.P. “Highly Efficient Fumed Silica Nanoparticles for Peptide Bond Formation: Converting Alanine to Alanine Anhydride” ACS Appl. Mater. Interfaces 2017, 9, 17653-17661.* IF = 7.504

Guo, C., Jordan, J.S., Yarger, J.L., Holland, G.P. “Highly Efficient Fumed Silica Nanoparticles for Peptide Bond Formation: Converting Alanine to Alanine Anhydride” ACS Appl. Mater. Interfaces 2017, 9, 17653-17661.* IF = 7.504

Koyanagi, G., Cao, K.J., T., Leriche, Yep, Onofrei, D., Holland, G.P., Mayer, M., Sept, D., Yang, J. “Lipids Inspired by Extremophiles and Eukaryotes Afford Serum-stable Membranes with Low Leakage” Chemistry-A European Journal. 2017, 23, 6757-6762. IF = 5.771


Gray, G.M., van der Vaart, A., Guo, C., Jones, J., Onofrei, D., Cherry, B.R., Yarger, J.L., Holland, G.P. “Secondary Structure Adopted by the Gly-Gly-X Repetitive Regions of Dragline Spider Silk” Int. J. Mol. Sci. 2016, 17, 2023.* [Invited Article, Special Issue on Silk-based Materials], IF = 3.257

Brown, J.E., Davidowski, S.K., Xu, D., Cebe, P., Onofrei, D., Holland, G.P., Kaplan, D.L. “Thermal and Structural Properties of Silk Biomaterials Plasticized by Glycerol” Biomacromolecules 2016, 17, 3911-3921, IF = 5.750

Finkelstein-Shapiro, D., Davidowski, S.K., Lee, P., Guo, C., Holland, G.P. Rajh, T., Gray, K.A., Yarger, J.L., Calatayud, M. “Direct Evidence of Chelated Geometry of Catechol on TiO2 by a Combined Solid-state NMR and DFT Study” J. Phys. Chem. C. 2016, 120, 23625-23630.* IF = 4.509

Koyanagi, T., Leriche, G., Yep, A., Onofrei, D., Holland, G.P., Mayer, M., Yang, J. “Effect of Headgroups on Small-Ion Permeability Across Archae-Inspired Tetraether Lipid Membranes” Chemistry-A European Journal. 2016, 22, 8074-8077. IF = 5.771

Davidowski, S. and Holland, G.P. “Solid-state NMR Characterization of Mixed Phosphonic Acid Ligand Binding and Organization on Silica Nanoparticles” Langmuir 2016, 32, 3252-3261.* IF = 3.993

Koyanagi, T., Leriche, G., Onofrei, D., Holland, G.P., Mayer, M., Yang, J. “Cyclohexane Rings Reduce Permeability to Small Ions in Archaea-inspired Tetraether Lipids” Angew. Chem. Int. Ed. Engl. 2016, 55, 1890-1893. IF = 11.709


Guo, C. and Holland, G.P. “Alanine Adsorption and Thermal Condensation at the Interface of Fumed Silica Nanoparticles: A Solid-state NMR Investigation” J. Phys. Chem. C. 2015, 119, 25663-25672.* IF = 4.509

Guzman, C.X., Calderon, R.M.K., Li, Z., Yamazaki, S., Peurifoy, S.R., Guo, C., Davidowski, S.K., Mazza, M.M.A., Han, Xu, Holland, G.P., Scott, A.M., Braunschweig, A.B. “Extended Charge Carrier Lifetimes in Hierarchical Donor-Acceptor Supramolecular Polymer Films” J. Phys. Chem. C. 2015, 119, 19584-19589. IF = 4.509

Xu, D., Guo, C., Holland, G.P. “Probing the Impact of Acidification on Spider Silk Assembly Kinetics” Biomacromolecules 2015, 16, 2072-2079.* IF = 5.750

Shi, X., Holland, G.P., Yarger, J.L. “Molecular Dynamics of Spider Dragline Silk Fiber Investigated by 2H MAS NMR” Biomacromolecules 2015, 16, 852-859.* IF = 5.750


Guo, C. and Holland, G.P. “Investigating Lysine Adsorption on Fumed Silica Nanoparticles” J. Phys. Chem. C. 2014, 118, 25792-25801.* IF = 4.509

Tarakeshwar, P., Palma, J.L., Holland, G.P., Fromme, P., Yarger, J.L., Mujica, V. “Probing the Nature of Charge Transfer at Nano-Bio Interfaces: Peptides on Metal Oxide Nanoparticles” J. Phys. Chem. Lett. 2014, 5, 3555-3559. IF = 8.539

Xu, D., Yarger, J.L., Holland, G.P. “Exploring the Backbone Dynamics of Native Spider Silk Proteins in Black Widow Silk Glands with Solution NMR Spectroscopy” Polymer, 2014, 55, 3879-3885.* IF = 3.775

Addison, J.B., Popp, T.M.O., Weber, W.S., Edgerly, J.S., Holland, G.P., Yarger, J.L. “Structural Characterization of Nanofiber Silk Produced by Embiopterans (webspinners)” RSC Advances, 2014, 4, 41301-41313. IF = 3.289

Shi, X., Yarger, J.L., Holland, G.P. “Elucidating Proline Dynamics in Spider Dragline Silk Fiber Using 2H-13C HETCOR MAS NMR” Chem. Commun. 2014, 50, 4856-4859.* IF = 6.567

Addison, J.B., Weber, W.S., Mou, Q., Ashton, N.N., Stewart, R.J., Holland, G.P., Yarger, J.L. “Reversible Assembly of b-sheet Nanocrystals within Caddisfly Silk” Biomacromolecules 2014, 15, 1269-1275. IF = 5.750


Asakura, T., Suzuki, Y., Nakazawa, Y., Holland, G.P., Yarger, J.L. “Elucidating Silk Structure Using Solid-state NMR” Soft Matter 2013, 9, 11440-11450. IF = 3.798

Jenkins, J.E., Sampath, S., Butler, E., Kim, J., Henning, R.W., Holland, G.P., Yarger, J.L. “Characterizing the Secondary Protein Structure of Black Widow Dragline Silk Using Solid-state NMR and X-ray Diffraction” Biomacromolecules 2013, 14, 3472-3483.* IF = 5.750

Fritzsching, K.J., Kim, J., Holland, G.P. “Probing Lipid-cholesterol Interactions in DOPC/eSM/Chol and DOPC/DPPC/Chol Model Lipid Rafts with DSC and 13C Solid-state NMR” Biochim. Biophys. Acta 2013, 1828, 1889-1898.* IF = 3.687

Holland, G.P., Mou, Q., Yarger, J.L. “Determining Hydrogen-bond Interactions in Spider Silk with 1H-13C HETCOR Fast MAS Solid-state NMR and DFT Proton Chemical Shift Calculations” Chem. Commun. 2013, 49, 6680-6682.* IF = 6.567

Shi, X., Holland, G.P., Yarger, J.L. “Amino Acid Analysis of Spider Dragline Silk Using 1H NMR Spectroscopy” Anal. Biochem. 2013, 440, 150-157.* IF = 2.219

Shi, X., Yarger, J.L., Holland, G.P. “Probing Site-specific 13C/15N-isotope Enrichment of Spider Silk with Liquid-state NMR Spectroscopy” Anal. Bioanal. Chem. 2013, 405, 3997-4008.* IF = 3.578

Addison, J.B., Ashton, N.N., Weber, W.S., Stewart, R.J., Holland, G.P., Yarger, J.L. “b-sheet Nanocrystalline Domains Formed from Phosphorylated Serine-rich Motifs in Caddisfly Larval Silk: A Solid-state NMR and XRD Study” Biomacromolecules 2013, 14, 1140-1148. IF = 5.750

Asakura, T., Suzuki, Y., Nakazawa, Y., Yazawa, K., Holland, G.P., Yarger, J.L. “Silk Structure Studied with Nuclear Magnetic Resonance” Prog. Nucl. Mag. Res. Sp. 2013, 69, 23-68. IF = 7.237

Shi, X., Yarger, J.L., Holland, G.P., “2H-13C HETCOR MAS NMR for Indirect Detection of 2H Quadrupole Patterns and Spin-lattice Relaxation Rates” J. Magn. Reson. 2013, 226, 1-12.* IF = 2.889

Pizzarello, S., Davidowski, S.K., Holland, G.P., Williams, L.B. “Processing of Meteoritic Organic Materials as a Possible Analog of Early Molecular Evolution in Planetary Environments” Proc. Natl. Acad. Sci. U.S.A 2013, 110, 15614-15619. [Featured on Spectroscopy Now] IF = 9.423


An, B., Jenkins, J.E., Sampath, S., Holland, G.P., Hinman, M., Yarger, J.L., Lewis, R.V. “Reproducing Natural Spider Silk’s Copolymer Behavior in Synthetic Silk Mimics” Biomacromolecules 2012, 13, 3938-3948. IF = 5.750

Blanchard, J.W., Groy, T.L., Yarger, J.L., Holland, G.P. “Investigating Hydrogen-bonded Phosphonic Acids with Proton Ultrafast MAS NMR and DFT Calculations” J. Phys. Chem. C. 2012, 116, 18824-18830.* IF = 4.509

Jenkins, J.E., Holland, G.P., Yarger, J.L. “High Resolution Magic Angle Spinning NMR Investigation of Silk Protein Structure within Major Ampullate Glands of Orb Weaving Spiders” Soft Matter 2012, 8, 1947-1954.* IF = 3.798

Teule, F., Addison, B., Copper, A.R., Ayon, J., Henning, R.W., Benmore, C.J., Holland, G.P., Yarger, J.L., Lewis, R.V. “Combining Flagelliform and Dragline Spider Silk Motifs to Produce Tunable Synthetic Biopolymer Fibers” Biopolymers 2012, 97, 418-431. IF = 2.248


Spektor, K., Nylen, J., Navrotsky, A., Hervig, R.L., Leinenweber, K., Holland, G.P., Haussermann, U. “Ultrahydrous Stishovite from High-pressure Hydrothermal Treatment of SiO2Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 20918-20922. IF = 9.423

Bo, A., Hinman, M.B., Holland, G.P., Yarger, J.L., Lewis, R.V. “Inducing b-sheets Formation in Synthetic Spider Silks by Aqueous Post-spin Stretching” Biomacromolecules 2011, 12, 2375-2381. IF = 5.750

Blanchard, J.W., Belieres, J.-P., Alam, T.M., Yarger, J.L., Holland, G.P. “NMR Determination of the Diffusion Mechanisms in Triethylamine-based Protic Ionic Liquids” J. Phys. Chem. Lett. 2011, 2, 1077-1081.* IF = 8.539

Pizzarello, S., Williams, L.B., Lehman, J., Holland, G.P., Yarger, J.L. “Abundant Ammonia in Primitive Asteroids and the Case for a Possible Exobiology” Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 4303-4306. IF = 9.423